Enhanced Weight Loss in Bangkok

Why does weight drift up as we get older?

If it seems like it’s getting harder and harder to lose weight as you get older, you’re not imagining things. “As you age, your metabolism starts to slow down, and a lot of your metabolism functions and organs and absorption—everything just gets a little less efficient,” says Katherine L Tucker, Ph.D., professor of nutritional epidemiology and director of the Center for Population Health at the University of Massachusetts-Lowell.

You now need fewer calories than ever just to maintain your body mass, let alone reduce it.

What does the research suggest?

Some long-term research has reported that men with clinically diagnosed testosterone deficiency who received testosterone replacement therapy (TRT) also experienced improvements in weight and body composition over time. In one German research cohort, participants receiving regular testosterone injections were observed to have reductions in body weight and BMI across several years.

It’s important to interpret these findings carefully:

• These results reflect outcomes in a specific group of men under medical supervision, and may not apply to everyone.
• Weight change is influenced by many factors (diet, activity, sleep, metabolic health, medications), so outcomes vary and cannot be guaranteed.
• TRT is prescribed to treat confirmed low testosterone (hypogonadism), not as a general weight-loss treatment.
• TRT is not a substitute for evidence-based obesity care or bariatric surgery when surgery is medically indicated.

At HE Clinic, we consider TRT only after a clinical assessment and appropriate blood tests confirm testosterone deficiency, and we provide ongoing monitoring to support safety and realistic expectations.

What is TRT?

Testosterone Replacement Therapy (TRT) is a doctor-prescribed treatment for men with clinically confirmed testosterone deficiency (hypogonadism). At HE Clinic, TRT is considered only after a medical consultation and appropriate blood testing confirm low testosterone levels together with compatible symptoms.

Testosterone levels can decline gradually with age, but some men develop abnormally low levels due to underlying medical factors. In hypogonadism, the testes do not produce enough testosterone for normal body function.

Common symptoms that may be associated with low testosterone

Symptoms vary and can overlap with other conditions, so diagnosis requires clinical assessment. Possible symptoms include:

• Low sex drive and reduced morning erections
• Erectile difficulties (may also have other causes)
• Low energy, reduced motivation, or persistent fatigue
• Low mood or irritability
• Reduced muscle mass/strength and increased body fat
• Reduced body hair or slower hair growth in some men

What to expect with TRT

If TRT is appropriate for you, the goal is to restore testosterone to a healthy range and improve symptoms related to testosterone deficiency. Some patients report improvements in:

• Energy and wellbeing
• Sex drive and sexual symptoms related to low testosterone
• Muscle maintenance, when combined with resistance training

Results vary, and TRT requires ongoing monitoring to support safety and effectiveness. Your clinician will explain expected outcomes, risks, and follow-up testing before starting treatment.

What does the research suggest?

Testosterone is a key male sex hormone involved in multiple body functions, including muscle maintenance, fat distribution, bone health, mood, and sexual health. In men with clinically confirmed testosterone deficiency (hypogonadism), low testosterone can be associated with changes in body composition, such as reduced lean muscle mass and increased fat mas,s which may make weight management more challenging for some individuals.

The testosterone–weight cycle

There is also a well-recognised relationship between excess body fat and testosterone levels. In many men, higher levels of body fat especially abdominal (visceral) fat are associated with lower testosterone, and lower testosterone may contribute to further unfavourable body composition changes. On the other hand, healthy weight loss and improved lifestyle factors can be associated with improvements in testosterone levels in some men.

A key point: this relationship is complex. Low testosterone may contribute to weight and body composition changes, but weight gain can also contribute to lower testosterone. That’s why a medical assessment is important before deciding on treatment.

What the research suggests

Some long-term observational studies have reported that men with obesity and low testosterone who received testosterone therapy showed improvements over time in measurements such as weight, waist circumference, and metabolic markers. In these studies, outcomes in treated groups sometimes differed from those who did not receive therapy.

However, it’s important to interpret these findings appropriately:

• Many of these studies are observational, meaning they can show associations but cannot prove that testosterone therapy alone caused the changes.
• Individual results vary and depend on many factors, including baseline health, lifestyle habits, concurrent treatments, and follow-up care.
• Testosterone therapy is not prescribed as a general weight-loss treatment. It is prescribed to treat medically confirmed testosterone deficiency and requires ongoing monitoring for safety.

How HE Clinic approaches TRT and weight goals

At HE Clinic, we position testosterone therapy as part of a medical, structured men’s health plan—not as a quick solution for weight loss. If you are experiencing symptoms suggestive of low testosterone, we start with:

• A medical consultation and lifestyle assessment
• Appropriate blood testing (often repeated to confirm results)
• A review of potential contributing factors, such as sleep, stress, medications, and metabolic health

If testosterone deficiency is confirmed and TRT is clinically appropriate, we discuss expected outcomes honestly:

• TRT may support energy, motivation, and muscle maintenance in some men
• Some men may experience body composition improvement over time when TRT is combined with resistance training, nutrition changes, and metabolic care
• Results are not guaranteed, and TRT is not a substitute for weight-loss medications or bariatric surgery when those are medically indicated

If your primary goal is fat loss, we may also discuss evidence-based weight management options (lifestyle support, metabolic evaluation, and prescription therapies when appropriate), then integrate hormone care only when it fits your diagnosis and safety profile.

Is there any other way of losing weight that actually works?

Yes, there are additional, evidence-based options, depending on your health profile.

• Prescription weight-loss medication (when appropriate): Options such as liraglutide (GLP-1) may help reduce appetite and support weight loss when combined with nutrition and lifestyle changes. Results vary, and eligibility requires a clinician assessment. It’s typically a once-daily pen injection under medical guidance.
• Cryolipolysis (fat freezing) for localised fat: A fat reduction treatment for stubborn pockets of fat and body contouring, not a weight-loss procedure. Best for selected patients near their target weight. Suitability and risks should be reviewed during consultation.
• Hormone evaluation / TRT (only if clinically indicated): TRT is prescribed for confirmed testosterone deficiency, not as a general weight-loss injection. In appropriate patients, it may support energy and body composition improvement alongside resistance training and a structured program. Monitoring is required.

Before starting: A consultation is recommended. If needed, blood tests may include glucose/HbA1c, CBC, liver/kidney function, and hormone testing (testosterone ± LH, PSA when indicated).

Combining treatments: Some patients may combine lifestyle support with medication and/or cryolipolysis. TRT is added only when medically appropriate.

Saxenda Pen (Liragrutide)

Saxenda® (liraglutide) is a prescription GLP-1 medicine used for long-term weight management in eligible adults, alongside a reduced-calorie diet and increased physical activity.

• Who it’s for: Adults with BMI ≥ 30, or BMI ≥ 27 with at least one weight-related condition (e.g., high blood pressure, type 2 diabetes, high cholesterol).
• How it works: Helps reduce appetite and support lower calorie intake in some patients.
• How it’s used: Once-daily self-injection with a pre-filled pen (abdomen, thigh, or upper arm). Dose is started low and increased gradually to improve tolerability.
• What to expect: Results vary; some patients lose meaningful weight, others less. Ongoing review helps decide whether to continue.
• Common side effects: Mainly gastrointestinal (nausea, vomiting, diarrhoea/constipation, abdominal discomfort), often improving over time.
• Safety: Requires clinician screening and monitoring; not suitable for everyone.

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