NAD+ Rejuvenation Therapy in Bangkok, Thailand

History of NAD+

NAD+ (nicotinamide adenine dinucleotide) has been studied for more than a century and is recognised as a fundamental coenzyme in cellular metabolism.

• 1906: Sir Arthur Harden and William John Young reported early findings related to NAD+ while studying fermentation.
• 1930s: Research in biochemistry expanded understanding of NAD+ as a widely distributed cofactor involved in energy-related reactions in living organisms.
• Mid-20th century: Key discoveries helped clarify how the body synthesises and recycles NAD+, including the identification of important enzymes and pathways (such as the Preiss–Handler pathway, described in 1958).
• Recent research: Interest in NAD+ has increased as scientists explore how NAD+-related pathways may influence cellular function, ageing biology, and physiological responses to factors such as exercise and nutrition. While these findings are scientifically significant, clinical outcomes in humans continue to be studied, and benefits can vary between individuals.

At HE Clinic Bangkok, we present NAD+ in a medically responsible way focused on patient screening, safety, and realistic expectations.

What is NAD+

None of us can live without NAD+. It plays a central role in helping the body convert nutrients into energy and supports many normal cellular functions.

NAD+ is involved in processes such as:

• Converting food into cellular energy
• Supporting normal DNA maintenance processes
• Supporting cellular stress responses and defence mechanisms
• Helping regulate circadian rhythm (the body’s internal clock)

However, NAD+ naturally declines with age

NAD+ levels tend to decrease as part of normal ageing. Lifestyle factors (sleep, nutrition, stress, and overall health) can also influence how we feel day to day. NAD+ IV is offered as one option some patients explore for wellness support after medical screening.

What if your NAD+ is Low?

Lower NAD+ levels have been associated with ageing-related changes and reduced cellular energy. While research continues, it’s important to separate biological associations from proven clinical outcomes.
Some people explore NAD+ IV when they experience concerns such as:

• Feeling persistently run down or low in energy
• Reduced resilience during high-stress periods
• Travel fatigue or disrupted sleep schedules

In response, NAD+ activates certain enzymes that may promote healthy ageing.

NAD+ plays a key role in helping your brain cells age well.

Potential Benefits

Research on NAD+ is ongoing, and evidence in humans is still developing. Benefits are not guaranteed and may vary by individual.

• Metabolic support: NAD+ plays a role in cellular energy production and metabolism. Some people explore NAD+ therapy as part of a broader plan for weight management, alongside nutrition, sleep, and physical activity.
• Cellular maintenance: NAD+ is involved in pathways related to DNA repair and oxidative stress response.
• Circadian rhythm support: NAD+ is linked to processes that influence the body’s internal clock. Some patients consider it for well-being support during travel or schedule disruption (e.g., jet lag), but responses vary.
• Muscle and healthy ageing (emerging evidence): NAD+ is being studied for its role in muscle function and age-related changes. Human clinical outcomes are still limited and not definitive.

Safety and Side Effects

NAD+ infusions are often tolerated in a clinical setting with appropriate screening and monitoring, but no treatment is risk-free. Possible side effects may include flushing, nausea, dizziness, headache, or discomfort at the IV site. Rarely, allergic reactions or vein irritation can occur.

Notes on dosing: Safety data can differ by delivery method (oral vs IV), dose, and individual health conditions. Any dosing decisions should be clinician-guided and based on medical assessment.

What NAD+ IV support

NAD+ IV is positioned as a wellness-focused service. Some patients report benefits such as:

• Feeling more “recharged” or mentally refreshed
• Improved sense of stamina or day-to-day energy
• Support during recovery after travel or busy schedules

Because individual responses vary, we focus on realistic expectations, appropriate dosing, and safety-first screening.

What to expect at your appointment

1. Consultation & screening
We review your goals, health history, allergies, and current medications.
2. Vital signs & suitability check
Your clinician confirms whether NAD+ IV is appropriate that day.
3. NAD+ infusion (sterile technique + monitoring)
The infusion is administered in-clinic with observation throughout.
4. Aftercare guidance
You’ll receive advice on hydration, rest, and follow-up based on your response.

Restoring NAD+ by supplementing NAD+ can dramatically decrease age-associated functional defects, counteracting many diseases of ageing, including neurodegenerative diseases.